Righty ho.....those who do not have a contact email on thier profile please Pm it to me.....
I have found a very good chapter in a recently published book relating to animal kidney disease. However I have no rights to access online. Mark you may have more luck as you will have more library rights than I currently do....The chapter breaks down like this;
Chapter 16
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Kidney Function and Damage
This article is not included in your organization's subscription. However, you may be able to access this article under your organization's agreement with Elsevier.
Jean-Pierre Brauna and Herve P. Lefebvrea
aDepartment of Physiopathology and Experimental Toxicology, National School of Veterinary Medicine of Toulouse, Toulouse, France
Available online 30 September 2008.
Chapter Outline
I. Introduction
II. Kidney morphology and function
A. General Structure of the Kidneys
B. Glomerulus and Filtration
C. Tubule: Reabsorption and Secretion
1. Parts of the tubule
2. Functions of the tubule
a. Small Hydrophilic Molecules
b. Electrolytes
c. Water
d. Acid-Base Regulation
e. Endocrine Functions
III. Tests of kidney function
A. Indirect Tests of Glomerular Function
1. Creatinine
a. Creatinine Metabolism
b. Preanalytical Factors of Variation
c. Analytical Factors of Variation
d. Reference Intervals and Physiological Factors of Variation
e. Variations of P-Creatinine in Disease
2. Urea
a. Urea Metabolism
b. Preanalytical Factors of Variation
c. Analytical Factors of Variation
d. Reference Intervals and Physiological Factors of Variation
e. Pathological Factors of Variation
f. Effects of Prolonged Increases of P-Urea: Carbamylated Hemoglobin
3. Cystatin C
B. Direct Tests of Glomerular Function
1. Determination of gfr
2. Variations of results of gfr determination according to procedure
a. Preanalytical Factors of Variation
b. Techniques of GFR Measurement
c. Reference Values and Physiological Factors of Variation
d. Variations with Disease
C. Tests of Tubule Function
1. Concentrating ability
a. Urine Osmolality versus Urine-Specific Gravity
b. Preanalytical Factors of Variation
c. Analytical Factors of Variation
d. Reference Values and Physiological Factors of Variation
e. Pathological Factors of Variation
2. Tests of water deprivation
3. Urine excretion of ions
a. Fractional Excretion
b. Preanalytical Factors of Variation of Ion Excretion
c. Analytical Factors of Variation
d. Reference Intervals and Physiological Factors of Variation
e. Pathological Factors of Variation
IV. Tests of kidney damage
A. Glomerular Damage
1. Proteinuria
a. Origin of Urinary Proteins
b. Protein concentration versus Daily Protein Output versus U-(Protein/Creatinine) Ratio
c. Preanalytical Factors of Variation
d. Techniques
e. Reference Values and Physiological Factors of Variation
f. Pathological Factors of Variation
2. Albuminuria-microalbuminuria
3. Urine protein electrophoresis
B. Tubule Damage
1. Urine enzyme activities
a. Pathopathology
b. Preanalytical Factors of Variation
c. Analytical Factors of Variation
d. Reference Intervals and Physiological Factors of Variation
e. Pathological Factors of Variation
2. Blood
V. Biochemical changes in kidney disease
A. Chronic Renal Failure
1. Development and progression of renal failure
2. Biochemical changes in animals with spontaneous crf
B. Acute Renal Failure
1. Definition, etiology, and pathophysiology
2. Urine and plasma biochemical findings in arf
C. Nephrotic Syndrome
D. Fanconi-Like Syndromes
Heres a link to the book on Elsevier...........
http://www.elsevier.com/wps/find/bookdescription.cws_home/714830/description
